BackgroundA significant U-shaped association between sleep duration and several morbidity (obesity, diabetes or cardiovascular disease) and mortality risks has been regularly reported.However, although the physiological pathways and risks associated with "too short sleep" (PurposeTo explore socio-demographic characteristics and comorbidities of "lo

In a number of cases, for example, when choosing the design of the exit part of a chimney, when taking into account the characteristics of the underlying surface and meteorological characteristics of the area, or as a means of verifying variant calculations in the ANSYS environment, a study of the trajectory of the smoke plume in natural conditions

Natural disasters nearly always catch societies by surprise, even though in hindsight historians invariably conclude that being caught off-guard in this way was in fact unfounded as both the Safety existence of the natural hazard which caused the disaster, and the societal conditions making communities vulnerable to the hazard, were clearly present

Abolishing the inhibitory signal of intracellular cAMP is Gift Card a prerequisite for effector T (Teff) cell function.The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs).We have previously shown that PDE8A, a PDE isoform with 40-100-fold greater affinity for cAMP than PDE4,

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